3-Fluoro-4-(methoxycarbonyl)benzeneboronic acid → HCID 66697313, compound

HRID 2096762Notes

Reaction equation

HRID 2096762 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH3:27])[C:9]([C:15]2[CH:26]=[N:25][C:18]3[O:19][CH2:20][C:21](=[O:24])[N:22]([CH3:23])[C:17]=3[CH:16]=2)([OH:14])[C:10]([F:13])([F:12])[F:11])=[C:4]([Cl:28])[CH:3]=1.[F:29][C:30]1[CH:31]=[C:32](B(O)O)[CH:33]=[CH:34][C:35]=1[C:36]([O:38][CH3:39])=[O:37]>>[CH3:39][O:38][C:36]([C:35]1[CH:34]=[CH:33][C:32]([C:2]2[CH:7]=[CH:6][C:5]([CH:8]([CH3:27])[C:9]([OH:14])([C:15]3[CH:26]=[N:25][C:18]4[O:19][CH2:20][C:21](=[O:24])[N:22]([CH3:23])[C:17]=4[CH:16]=3)[C:10]([F:12])([F:11])[F:13])=[C:4]([Cl:28])[CH:3]=2)=[CH:31][C:30]=1[F:29])=[O:37]

Participants

3

Reactant 2

HCID 27828183-Fluoro-4-(methoxycarbonyl)benzeneboronic acidHCID 67546667HCID 67546667, compound

Product 1

HCID 66697313HCID 66697313, compound

Procedure

In analogy to Example 17, step 2, 7-[2-(4-bromo-2-chloro-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-1-methyl-1H-pyrido[2,3-b][1,4]oxazin-2-one was reacted with 3-fluoro-4-methoxycarbonylphenylboronic acid to give the title compound as a colorless solid. MS (m/e)=553.4 [M+H+].

Sources & evidence

ORD record
ord-21c95d653dc0413ca04427faeb3e2abc
Source dataset
uspto-grants-2013_05
Patent number
US08450313B2

Reaction notes

Loading…