HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4-Chloro-3-(ethoxycarbonyl)phenyl)boronic acid → 2-Chloro-5-{3-chloro-4-[3,3,3-trifluoro-2-hydroxy-1-methyl-2-(4-methyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-propyl]-phenoxy}-benzoic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4-Chloro-3-(ethoxycarbonyl)phenyl)boronic acid | HCID 44119820 | — |
| Reactant | 6-[(2-chloro-4-hydroxy-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-4-methyl-4H-benzo[1,4]oxazin-3-one | HCID 66697239 | — |
| Catalyst | Cupric acetate | HCID 8895 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 2-Chloro-5-{3-chloro-4-[3,3,3-trifluoro-2-hydroxy-1-methyl-2-(4-methyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-propyl]-phenoxy}-benzoic acid ethyl ester | HCID 66697296 | — |
Reaction Steps
In analogy to Example 5, 6-[2-(2-chloro-4-hydroxy-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-4-methyl-4H-benzo[1,4]oxazin-3-one (Example 56, step 4) was reacted with 4-chloro-3-(ethoxycarbonyl)benzeneboronic acid, copper-(II)-acetate and pyridine to give the title compound as a off-white solid. MS (m/e, ISP neg. ion)=596.3 [M−H+]
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08450313B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-6eda1abb029541b2a53754d0435e82fa |
| Source note | uspto-grants-2013_05 |