HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 2-Chloro-4-(3-chloro-4-methyl-phenoxy)-benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-Chloro-4-methylphenol | HCID 14853 | — |
| Reactant | 2-Chloro-4-fluorobenzonitrile | HCID 109000 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | 2-Chloro-4-(3-chloro-4-methyl-phenoxy)-benzonitrile | HCID 66697094 | 99.1% |
Reaction Conditions
| Temperature | 120 °C |
|---|
Reaction Steps
To a solution of 3-chloro-4-methylphenol (7.5 g) and 2-chloro-4-fluorobenzonitrile (8.14 g) in N,N-dimethylacetamide (23 ml) was added potassium carbonate (8.55 g). The mixture was stirred for 5 hours at 120° C. The mixture was poured into ice water and extracted with ethyl acetate. The organic phase was washed with water, dried (MgSO4), filtered and concentrated to dryness to give the title compound (14.42 g) as a colorless solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08450313B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-7b5f33c6e6c24a14951592ad86eeef09 |
| Source note | uspto-grants-2013_05 |