HRID2096876

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2758810

ethyl 6-bromopyridine-2-carboxylate

C8H8BrNO2

结构：CC(c1ccc(B2OC(C)(C)C(C)(C)O2)cc1Cl)C(O)(c1ccc2oc(=O)n(C)c2c1)C(F)(F)F

HCID66697095

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)c1cccc(-c2ccc(C(C)C(O)(c3ccc4oc(=O)n(C)c4c3)C(F)(F)F)c(Cl)c2)n1

HCID66697036

未命名化合物

PROCEDURE

实验过程

The title compound was prepared in analogy to Example 186, step 2 from 5-{2-[2-chloro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-1-hydroxy-1-trifluoromethyl-propyl}-3-methyl-3H-benzooxazol-2-one (obtained in Example 186, step 1) with ethyl-6-bromopyridine-2-carboxylate [CAS Reg. No. 21190-88-5]. MS (m/e)=535.2 [M+H+].

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6be95ea0f086426b9f992f28c36cbdce
来源数据集: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08450313B2
来源说明: uspto-grants-2013_05

反应 SMILES

[Cl:1][C:2]1[CH:7]=[C:6](B2OC(C)(C)C(C)(C)O2)[CH:5]=[CH:4][C:3]=1[CH:17]([CH3:35])[C:18]([C:24]1[CH:25]=[CH:26][C:27]2[O:31][C:30](=[O:32])[N:29]([CH3:33])[C:28]=2[CH:34]=1)([OH:23])[C:19]([F:22])([F:21])[F:20].[CH2:36]([O:38][C:39]([C:41]1[CH:46]=[CH:45][CH:44]=[C:43](Br)[N:42]=1)=[O:40])[CH3:37]>>[CH2:36]([O:38][C:39]([C:41]1[CH:46]=[CH:45][CH:44]=[C:43]([C:6]2[CH:5]=[CH:4][C:3]([CH:17]([CH3:35])[C:18]([OH:23])([C:24]3[CH:25]=[CH:26][C:27]4[O:31][C:30](=[O:32])[N:29]([CH3:33])[C:28]=4[CH:34]=3)[C:19]([F:22])([F:20])[F:21])=[C:2]([Cl:1])[CH:7]=2)[N:42]=1)=[O:40])[CH3:37]