Ammonium Chloride → HCID 66954483, compound

Participants

Reaction Conditions

Reaction Steps

Methyllithium (1.6 M in diethyl ether, 4.88 mL, 7.81 mmol) was added dropwise to a stirred solution of 6′-bromospiro[cyclohexane-1,3′-pyrrolo[3,2-b]pyridine]-2′,4(1′H)-dione (preparation 18, 1.00 g, 3.39 mmol) in tetrahydrofuran (30 mL) at −78° C. The mixture was warmed to 0° C. over 3 h and stirred overnight at ambient temperature. Additional methyllithium (1.6 M in diethyl ether, 4.24 mL, 6.78 mmol) was added dropwise at −78° C. and the mixture was warmed to ambient temperature stirred overnight at ambient temperature. Saturated aqueous ammonium chloride solution (20 mL) was added to the reaction and the mixture was extracted with ethyl acetate. The organic layer was separated, washed with brine, dried (MgSO4) and evaporated. Purification of the residue by flash chromatography (0.1% Et3N in 1:1 to 3:1 ethyl acetate/hexanes) gave the two pure isomers of the title compound.

Provenance & Evidence