Water → HCID 44476050, compound

Participants

Reaction Steps

To a solution of 6-(3-(4-methoxybenzylamino)-6-methylbenzo[d]isoxazol-7-yl)-2′,3′,5′,6′-tetrahydrospiro[indoline-3,4′-pyran]-2-one (example 10, 0.12 g, 0.26 mmol) in dichloromethane (2 mL) was added trifluoroacetic acid (2 mL) and the solution was stirred at room temperature for 5 hours. Water and solid sodium hydrogen carbonate were added in order to neutralize the trifluoroacetic acid. Ethyl acetate was added and the organic phase was separated, dried (MgSO4), filtered and evaporated under reduced pressure. The residue was purified by flash chromatography (96:4 dichloromethane/methanol) to yield the title compound (38 mg, 44%) as a white solid.

Provenance & Evidence