HuagongsheHuagongshe Chemistry Print Report · For research reference only
Borane;tetrahydrofuran → HCID 59161747, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Borane;tetrahydrofuran | HCID 2723981 | — |
| Reactant | alpha-(((1,1-Dimethylethoxy)carbonyl)amino)-3-thiopheneacetic acid | HCID 2734582 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 59161747 | HCID 59161747 | — |
Reaction Steps
To (±)-2-(tert-butoxycarbonylamino)-2-(thiophen-3-yl)acetic acid in THF at 0° C. was added BH3-THF dropwise. The solution was allowed to warm to room temperature and stirred for an additional 2 hours. The solution was cooled to 0° C., quenched with AcOH (10%)/MeOH and evaporated. Column chromatography (SiO2, EtOAc) gave pure tert-butyl 2-hydroxy-1-(thiophen-3-yl)ethylcarbamate (E1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08450344B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-a1365bf5b24442218bf50e083d9b1554 |
| Source note | uspto-grants-2013_05 |