Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Chloride | HCID 5234 | — |
| Reactant | Sodium Cyanide | HCID 8929 | — |
| Reactant | HCID 59161738 | HCID 59161738 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 59161750 | HCID 59161750 | — |
Reaction Steps
To 2-(tert-butoxycarbonylamino)-2-(thiophen-3-yl)ethyl 4-methylbenzenesulfonate (E2) in DMSO was added NaCN, and the solution was heated to 90° C. for 2 hours. The reaction was cooled, poured into NaCl (sat), and extracted with EtOAc. The organics were dried (Na2SO4), filtered, and evaporated. Column chromatography (SiO2, 25% EtOAc/Hexanes) gave pure tert-butyl 2-cyano-1-(thiophen-3-yl)ethylcarbamate (E3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08450344B2 |
|---|
| Source dataset | uspto-grants-2013_05 |
|---|
| ORD ID | ord-6b2198e935334dd5a47bc7384cee988b |
|---|
| Source note | uspto-grants-2013_05 |
|---|
