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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2097227Generated: October 31, 2026

Hydrochloric Acid → 3-Amino-2-(thiophen-3-yl)propanoic acid

https://huagongshe.com/reaction/2097227

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantMethyl 3-(1,3-dioxoisoindolin-2-yl)-2-(thiophen-3-yl)propanoateHCID 59161752—
Product3-Amino-2-(thiophen-3-yl)propanoic acidHCID 19756633—

Reaction Steps

To methyl 3-(1,3-dioxoisoindolin-2-yl)-2-(thiophen-3-yl)propanoate (E45) was added 6 N HCl, and the solution was refluxed for 4 hours. The solvents were evaporated to give 3-amino-2-(thiophen-3-yl)propanoic acid (E46).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08450344B2
Source datasetuspto-grants-2013_05
ORD IDord-576b7119b1e04b73bf84abea6f5cf84d
Source noteuspto-grants-2013_05