HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3-Chlorophenyl)boronic acid → 5-(2,4-Bis-benzyloxy-5-chloro-phenyl)-4-(3-chloro-phenyl)-isoxazole-3-carboxylic acid ethylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3-Chlorophenyl)boronic acid | HCID 2734323 | — |
| Reactant | 5-(2,4-Bis(benzyloxy)-5-chlorophenyl)-4-bromo-N-ethylisoxazole-3-carboxamide | HCID 24774042 | — |
| Product | 5-(2,4-Bis-benzyloxy-5-chloro-phenyl)-4-(3-chloro-phenyl)-isoxazole-3-carboxylic acid ethylamide | HCID 59264760 | 55% |
Reaction Steps
5-(2,4-Bis-benzyloxy-5-chloro-phenyl)-4-bromo-isoxazole-3-carboxylic acid ethylamide (60 mg, 0.11 mmol), and 3-chlorobenzene boronic acid (23 mg, 1.3 equiv.) were coupled together using the suzuki method previously described to provide 35 mg (55% yield) of the crude as a brown powder which was taken on to the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08450310B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-10ffab5719ba40c084b706fc7f59b5c6 |
| Source note | uspto-grants-2013_05 |