4-Fluorophenylboronic acid → HCID 59264720, compound

HRID 2097306Notes

Reaction equation

HRID 2097306 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:12]([Cl:23])=[CH:11][C:10]=1[C:24]1[O:28][N:27]=[C:26]([C:29]([NH2:31])=[O:30])[C:25]=1I)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:33][C:34]1[CH:39]=[CH:38][C:37](B(O)O)=[CH:36][CH:35]=1>>[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:12]([Cl:23])=[CH:11][C:10]=1[C:24]1[O:28][N:27]=[C:26]([C:29]([NH2:31])=[O:30])[C:25]=1[C:37]1[CH:38]=[CH:39][C:34]([F:33])=[CH:35][CH:36]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 2856454-Fluorophenylboronic acidHCID 68454107HCID 68454107, compound

Product 1

HCID 59264720HCID 59264720, compound

Procedure

5-(2,4-Bis-benzyloxy-5-chloro-phenyl)-4-iodo-isoxazole-3-carboxylic acid amide (0.45 g, 0.80 mmol) was cross coupled to 4-fluorophenylboronic acid (0.17 g, 1.5 equiv.) using the standard conditions described above. The crude product, an orange solid (0.40 g), was taken on to the next step without further purification.

Workup

  1. customThe crude product, an orange solid (0.40 g), was taken on to the next step without further purification

Sources & evidence

ORD record
ord-5568b3cae1644d539b4b4b7079d1347e
Source dataset
uspto-grants-2013_05
Patent number
US08450310B2

Reaction notes

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