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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2097325Generated: October 31, 2026

3-Ethoxy-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dione → 3-[6-(4-Trifluoromethylphenoxy)-hexylamino]-4-(pyridin-4-yl-amino)-cyclobut-3-ene-1,2-dione

https://huagongshe.com/reaction/2097325

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Ethoxy-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dioneHCID 10680319—
Reactant6-(4-Trifluoromethylphenoxy)-hexylamineHCID 23132429—
Product3-[6-(4-Trifluoromethylphenoxy)-hexylamino]-4-(pyridin-4-yl-amino)-cyclobut-3-ene-1,2-dioneHCID 11654952—

Reaction Steps

The title compound was prepared according to the procedure described in example 1B starting from 3-ethoxy-4-(pyridin-4-yl-amino)-3-cyclobutene-1,2-dione prepared according to example 7A and 6-(4-trifluoromethylphenoxy)-hexylamine. The reaction mixture was heated to reflux for 4 hours instead of stirring 18 h at r.t.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08450348B2
Source datasetuspto-grants-2013_05
ORD IDord-f5d974cd25ac40799bdda1d2e17b9d6b
Source noteuspto-grants-2013_05