2-Aminopyridine → HCID 10536778, compound

Participants

Reaction Steps

2-Aminopyridine (630 mg, 6.7 mmol) was added to a solution of 3,4-diethoxy-3-cyclobutene-1,2-dione (1.0 mL, 6.7 mmol) in EtOH (10 mL). The mixture was heated to reflux for 2.5 h, filtered and the filtrate was concentrated under reduced pressure. The residue was purified by flash chromatography (800 mL hexanes/EtOAc 3:1, 1.5 L hexanes/EtOAc 1:1) to give 431 mg (29%) of the title compound as a yellow powder.

Provenance & Evidence