3-(Pyridin-3-ylamino)-4-ethoxy-cyclobut-3-ene-1,2-dione → 3-[6-(4-(2-Morpholin-4-yl-ethoxy)-phenoxy)-hexylamino]-4-(pyridin-3-yl-amino)-cyclobut-3-ene-1,2-dione

HRID 2097331Notes

Reaction equation

HRID 2097331 reaction equation
C(O[C:4]1[C:5](=[O:16])[C:6](=[O:15])[C:7]=1[NH:8][C:9]1[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=1)C.[N:17]1([CH2:23][CH2:24][O:25][C:26]2[CH:39]=[CH:38][C:29]([O:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][NH2:37])=[CH:28][CH:27]=2)[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1>>[N:17]1([CH2:23][CH2:24][O:25][C:26]2[CH:39]=[CH:38][C:29]([O:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][NH:37][C:4]3[C:5](=[O:16])[C:6](=[O:15])[C:7]=3[NH:8][C:9]3[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=3)=[CH:28][CH:27]=2)[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1

Participants

3

Reactant 2

HCID 105129913-(Pyridin-3-ylamino)-4-ethoxy-cyclobut-3-ene-1,2-dioneHCID 231324536-[4-(2-Morpholin-4-yl-ethoxy)-phenoxy]-hexylamine

Product 1

HCID 115333183-[6-(4-(2-Morpholin-4-yl-ethoxy)-phenoxy)-hexylamino]-4-(pyridin-3-yl-amino)-cyclobut-3-ene-1,2-dioneYield 76%

Procedure

The title compound was prepared according to the procedure described in example 1B starting from 3-ethoxy-4-(pyridin-3-yl-amino)-3-cyclobutene-1,2-dione prepared according to example 1A and 6-[4-(2-morpholin-4-yl-ethoxy)-phenoxy]-hexylamine.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-f6df63f356d74892bebe7c4fa00f387b
Source dataset
uspto-grants-2013_05
Patent number
US08450348B2

Reaction notes

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