3-Ethoxy-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dione → 3-[4-(4-Chlorophenoxymethyl)-benzylamino]-4-(pyridin-4-yl-amino)-cyclobut-3-ene-1,2-dione

HRID 2097338Notes

Reaction equation

HRID 2097338 reaction equation
C(O[C:4]1[C:5](=[O:16])[C:6](=[O:15])[C:7]=1[NH:8][C:9]1[CH:14]=[CH:13][N:12]=[CH:11][CH:10]=1)C.[Cl:17][C:18]1[CH:33]=[CH:32][C:21]([O:22][CH2:23][C:24]2[CH:31]=[CH:30][C:27]([CH2:28][NH2:29])=[CH:26][CH:25]=2)=[CH:20][CH:19]=1>>[Cl:17][C:18]1[CH:19]=[CH:20][C:21]([O:22][CH2:23][C:24]2[CH:31]=[CH:30][C:27]([CH2:28][NH:29][C:4]3[C:5](=[O:16])[C:6](=[O:15])[C:7]=3[NH:8][C:9]3[CH:10]=[CH:11][N:12]=[CH:13][CH:14]=3)=[CH:26][CH:25]=2)=[CH:32][CH:33]=1

Participants

3

Reactant 2

HCID 106803193-Ethoxy-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dioneHCID 231324444-(4-Chloro-phenoxymethyl)-benzylamine

Product 1

HCID 116331313-[4-(4-Chlorophenoxymethyl)-benzylamino]-4-(pyridin-4-yl-amino)-cyclobut-3-ene-1,2-dioneYield 71%

Procedure

The title compound was prepared according to the procedure described in example 1B starting from 3-ethoxy-4-(pyridine-4-yl-amino)-3-cyclobutene-1,2-dione prepared according to example 7A and 4-(4-chlorophenoxy-methyl)-benzylamine.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-f2c6d7c3061444a889bb34179c013312
Source dataset
uspto-grants-2013_05
Patent number
US08450348B2

Reaction notes

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