Potassium Carbonate → Phenol

Participants

Reaction Conditions

Reaction Steps

4-(2-Morpholin-4-yl-ethoxy)-phenol (3.39 g, 15.2 mmol), N-(6-bromohexyl)-phthalimide (4.72 g, 15.2 mmol) and K2CO3 (4.20 g, 30.4 mmol) were suspended in DMF (35 mL) under an atmosphere of argon and stirred at 95° C. for 17 h. The solvent was evaporated under reduced pressure and the residue was partitioned between water (150 mL) and CH2Cl2 (150 mL). The aqueous layer was extracted with CH2Cl2 (2×100 mL), the combined org. layers were dried over Na2SO4, filtered and the solvent was removed under reduced pressure. The residue was purified by flash chromatography (EtOAc) to give the title compound together with some starting phenol (≈2:1). The mixture was used for subsequent reactions without further purification.

Provenance & Evidence