反应详情

Reaction was carried out in the same manner as in Example 1-(b) except for using 1.54 g (2.53 mmol) of 2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-3-methyl-1,5-bis(2-trimethylsilylethoxymethyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one obtained in Example 4-(a) in place of 2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-1-(2-trimethylsilylethoxymethyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one. After completion of the reaction, water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer after separation was washed successively with water and then with a saturated aqueous solution of sodium chloride, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The obtained residue was applied to silica gel column chromatography (Eluent; hexane:ethyl acetate=19:1→1:1 (V/V)), and the fractions containing the desired compound were concentrated under reduced pressure to obtain 1.11 g of the title compound as a white solid. (Yield: 92%)

1. customReaction
2. additionwas added to the reaction mixture
3. extractionthe mixture was extracted with ethyl acetate
4. customThe organic layer after separation
5. washwas washed successively with water
6. dry with materialwith a saturated aqueous solution of sodium chloride, dried over anhydrous magnesium sulfate
7. concentrationconcentrated under reduced pressure
8. additionthe fractions containing the desired compound
9. concentrationwere concentrated under reduced pressure