Ammonia → HCID 136346660, compound

Participants

Reaction Steps

To 313 mg (0.500 mmol) of 1-benzyloxymethyl-2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-3-isopropyl-5-(2-trimethylsilylethoxymethyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one obtained in Example 7-(a) were added 15 ml of ethanol, 1.6 ml of 28% aqueous ammonia and 39 mg of 5% palladium-active carbon, and the mixture was stirred under 1 atm hydrogen atmosphere at 30° C. for 7 days. After completion of the reaction, the reaction suspension was filtered, and the filtrate was concentrated under reduced pressure. The obtained residue was applied to silica gel column chromatography (Eluent; toluene:ethyl acetate=9:1→4:1 (V/V)), and the fractions containing the desired compound were concentrated under reduced pressure to obtain 152 mg of the title compound as a white foam. (Yield: 60%)

Provenance & Evidence