HCID 136346661, compound → HCID 135620501, compound

HRID 2097381Notes

Reaction equation

HRID 2097381 reaction equation
[CH2:1]([C:5]1[C:13]2[C:12](=[O:14])[N:11](COCC[Si](C)(C)C)[N:10]=[CH:9][C:8]=2[NH:7][C:6]=1[C:23]1[CH:28]=[CH:27][C:26]([O:29][CH:30]([F:32])[F:31])=[C:25]([O:33][CH:34]2[CH2:36][CH2:35]2)[CH:24]=1)[CH2:2][CH2:3][CH3:4]>C(O)C>[CH2:1]([C:5]1[C:13]2[C:12](=[O:14])[NH:11][N:10]=[CH:9][C:8]=2[NH:7][C:6]=1[C:23]1[CH:28]=[CH:27][C:26]([O:29][CH:30]([F:31])[F:32])=[C:25]([O:33][CH:34]2[CH2:35][CH2:36]2)[CH:24]=1)[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 1

HCID 136346661HCID 136346661, compound

Product 1

HCID 135620501HCID 135620501, compoundYield 95.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Reaction was carried out in the same manner as in Example 6-(c) except for using 3.94 g (7.58 mmol) of 3-butyl-2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-5-(2-trimethylsilylethoxymethyl)-1,5-dihydropyrrolo[2,3-d]-pyridazin-4-one obtained in Example 8-(b) in place of 2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-3-propyl-5-(2-trimethylsilylethoxymethyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one, and post treatment was carried out except for using ethanol in place of methanol, whereby 2.81 g of the title compound was obtained as a white solid. (Yield: 95%)

Workup

  1. customReaction

Sources & evidence

ORD record
ord-a59da31a49154a449ce5391c9bcbebef
Source dataset
uspto-grants-2013_05
Patent number
US08450319B2

Reaction notes

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