2-(3-Cyclopropoxy-4-difluoromethoxyphenyl)-3-triethylsilylethynyl-1-(2-trimethylsilylethoxymethyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one → 2-(3-Cyclopropoxy-4-difluoromethoxyphenyl)-3-ethynyl-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one

Participants

Reaction Steps

Reaction was carried out in the same manner as in Example 4-(b) except for using 32 mg (0.053 mmol) of 2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-3-triethylsilylethynyl-1-(2-trimethylsilylethoxymethyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one obtained in Example 16-(a) in place of 2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-3-methyl-1,5-bis(2-trimethylsilylethoxymethyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one. After completion of the reaction, water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer after separation was washed successively with water and then with a saturated aqueous solution of sodium chloride, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. To the obtained concentrate were added methanol and water, and the mixture was subjected to ultrasonic wave treatment and the precipitated solid was collected by filtration. The obtained solid was washed successively with water and then with diethyl ether and dried under reduced pressure to obtain 10 mg of the title compound as a beige solid. (Yield: 51%)

Provenance & Evidence