2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-1,5-bis(2-trimethylsilylethoxymethyl)-3-[1-(2-trimethylsilylethoxymethyl)-1H-pyrazol-4-yl]-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one → 2-(3-Cyclopropoxy-4-difluoromethoxyphenyl)-3-(4-pyrazolyl)-5-(2-trimethylsilylethoxymethyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one

Participants

Reaction Steps

Reaction and post treatment were carried out in the same manner as in Example 4-(b) except for using 190 mg (0.241 mmol) of 2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-1,5-bis(2-trimethylsilylethoxymethyl)-3-[1-(2-trimethylsilylethoxymethyl)-1H-pyrazol-4-yl]-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one obtained in Example 18-(a) in place of 2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-3-methyl-1,5-bis(2-trimethylsilylethoxymethyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one, whereby 101 mg of the title compound was obtained as a white solid. (Yield: 79%)

Provenance & Evidence