Hydrochloric Acid → HCID 66602774, compound

Participants

Reaction Steps

To 278 mg (0.413 mmol) of 3-benzyl-1-benzyloxymethyl-2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-5-(2-trimethylsilylethoxymethyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one obtained in Example 19-(a) was added 3.3 ml of 1,4-dioxane solution containing 4N hydrogen chloride, and the mixture was stirred at room temperature for 3 hours. After completion of the reaction, the reaction mixture was concentrated under reduced pressure, to the obtained solid were added 8.6 ml of methanol and 4.3 ml of 28% aqueous ammonia, and the mixture was stirred at room temperature for 1 hour. Then, the solution was concentrated under reduced pressure, water was added to the obtained concentrate, and the precipitated solid was collected by filtration. The obtained solid was washed with water and dried under reduced pressure to obtain 198 mg of the title compound as a white solid. (Yield: 88%)

Provenance & Evidence