反应详情

To 26 ml of ethanol solution containing 1.08 g (1.60 mmol) of 2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-3-(1-pentenyl)-1,5-bis(2-trimethylsilylethoxymethyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one obtained in the same manner as in Example 68-(a) was added 43.8 mg of platinum oxide, and the mixture was stirred under 1 atm hydrogen atmosphere at room temperature for 3 hours. After completion of the reaction, the insoluble material was filtered off from the reaction mixture, and the filtrate was concentrated under reduced pressure. The residue was applied to silica gel column chromatography (Eluent; hexane:ethyl acetate=1:3 (V/V)), and the fractions containing the desired compound were concentrated under reduced pressure to obtain 0.66 g of the title compound as a colorless oil. (Yield: 626).

1. customobtained in the same manner as in Example 68-(a)
2. customAfter completion of the reaction
3. filtrationthe insoluble material was filtered off from the reaction mixture
4. concentrationthe filtrate was concentrated under reduced pressure
5. additionthe fractions containing the desired compound
6. concentrationwere concentrated under reduced pressure