(Cyclopropylmethyl)triphenylphosphonium bromide → HCID 66602566, compound

HRID 2097452Notes

Reaction equation

HRID 2097452 reaction equation
[CH:1]1([O:4][C:5]2[CH:6]=[C:7]([C:15]3[N:32]([CH2:33][O:34][CH2:35][CH2:36][Si:37]([CH3:40])([CH3:39])[CH3:38])[C:18]4[CH:19]=[N:20][N:21]([CH2:24][O:25][CH2:26][CH2:27][Si:28]([CH3:31])([CH3:30])[CH3:29])[C:22](=[O:23])[C:17]=4[C:16]=3[CH:41]=O)[CH:8]=[CH:9][C:10]=2[O:11][CH:12]([F:14])[F:13])[CH2:3][CH2:2]1.[Br-].[CH:44]1([CH2:47][P+](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[CH2:46][CH2:45]1>>[CH:1]1([O:4][C:5]2[CH:6]=[C:7]([C:15]3[N:32]([CH2:33][O:34][CH2:35][CH2:36][Si:37]([CH3:40])([CH3:38])[CH3:39])[C:18]4[CH:19]=[N:20][N:21]([CH2:24][O:25][CH2:26][CH2:27][Si:28]([CH3:31])([CH3:30])[CH3:29])[C:22](=[O:23])[C:17]=4[C:16]=3[CH:41]=[CH:47][CH:44]3[CH2:46][CH2:45]3)[CH:8]=[CH:9][C:10]=2[O:11][CH:12]([F:14])[F:13])[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 3084208(Cyclopropylmethyl)triphenylphosphonium bromideHCID 86627032HCID 86627032, compound

Product 1

HCID 66602566HCID 66602566, compoundYield 71.2%

Procedure

Reaction and post treatment were carried out in the same manner as in Example 68-(a) except for using 0.62 g (1.00 mmol) of 2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-3-formyl-1,5-bis(2-trimethylsilylethoxymethyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one obtained in the same manner as in Example 15-(a), and using 1.19 g (3.00 mmol) of cyclopropylmethyltriphenylphosphonium bromide in place of butyltriphenylphosphonium bromide, whereby 0.47 g of the title compound was obtained as a colorless oil. (Yield: 71%)

Workup

  1. customReaction and post treatment
  2. customobtained in the same manner as in Example 15-(a)

Sources & evidence

ORD record
ord-e16f9ecbe7b84c64a366a1d8c56a4f19
Source dataset
uspto-grants-2013_05
Patent number
US08450319B2

Reaction notes

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