反应详情

Reaction and post treatment were carried out in the same manner as in Example 71-(a) except for using 1.74 g (2.80 mmol) of 2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-3-formyl-1,5-bis(2-trimethylsilylethoxymethyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one obtained in the same manner as in Example 15-(a), and using 6 ml of toluene solution containing 27w % 27 wt % 3-methyl-1-butynyl magnesium bromide prepared from ethyl magnesium bromide and 3-methyl-1-butyne in place of tetrahydrofuran solution containing ethynyl magnesium bromide, whereby 1.30 g of the title compound was obtained as a white foam. (Yield: 67%)

1. customReaction and post treatment
2. customobtained in the same manner as in Example 15-(a)