Hydrochloric Acid → HCID 57571707, compound

Participants

Reaction Steps

To 100 ml of 1,4-dioxane solution containing 33.9 g (0.10 mol) of 2-cyclopropylmethoxy-1-iodo-3-methoxymethoxybenzene obtained in Reference example 12-(b) was added 150 ml of 1,4-dioxane solution containing 4N hydrogen chloride, and the mixture was stirred at room temperature for 6 hours. After completion of the reaction, 100 ml of water was added to the reaction mixture, and the resulting mixture was extracted with diethyl ether. The organic layer after separation was washed with a saturated aqueous solution of sodium chloride, dried over anhydrous sodium sulfate and then concentrated under reduced pressure. The obtained residue was applied to silica gel column chromatography (Eluent; hexane:ethyl acetate=9:1 (V/V)), and the fractions containing the desired compound were concentrated under reduced pressure to obtain 22.3 g of the title compound as a colorless oil. (Yield: 77%)

Provenance & Evidence