Hydrochloric Acid → 3-Bromo-6-difluoromethoxy-2-iodophenol

Participants

Reaction Steps

To 59.5 ml of methanol solution containing 8.1 g (22 mmol) of 1-bromo-3-cyclopropylmethoxy-4-difluoromethoxy-2-iodobenzene obtained in Reference example 12-(e) was added 59.5 ml of conc. hydrochloric acid, and the mixture was refluxed for 4 hours. After completion of the reaction, water was added to the reaction mixture, and the mixture was extracted with diethyl ether. The organic layer after separation was washed with a saturated aqueous solution of sodium chloride, dried over anhydrous sodium sulfate and then concentrated under reduced pressure. The obtained residue was applied to silica gel column chromatography (Eluent; hexane:ethyl acetate=9:1 (V/V)), and the fractions containing the desired compound were concentrated under reduced pressure to obtain 6.9 g of the title compound as a colorless solid. (Yield: 87%)

Provenance & Evidence