Phenylboronic Acid → Ethyl 1-benzyloxymethyl-5-(3-cyclopropoxy-4-difluoromethoxyphenyl)-2-formyl-4-(6-methoxy-2-pyridylmethyl)-1H-pyrrol-3-carboxylate

Participants

Reaction Steps

Reaction and post treatment were carried out in the same manner as in Reference example 31 except for using 875 mg (1.80 mmol) of ethyl 1-benzyloxymethyl-5-bromo-2-formyl-4-(6-methoxy-2-pyridylmethyl)-1H-pyrrol-3-carboxylate obtained in Reference example 42-(b) in place of 2-chloro-3-iodo-1-(2-trimethylsilylethoxymethyl)-1,5-dihydropyrrolo-[2,3-d]pyridazin-4-one, and using 880 mg (2.70 mmol) of 2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane obtained in Reference example 1-(a) in place of phenylboronic acid, respectively, whereby 1.15 g of the title compound was obtained as a yellowish oil substantially quantitatively.

Provenance & Evidence