1-(Diphenylmethyl)azetidin-3-ol → HCID 58073127, compound

HRID 2097576Notes

Reaction equation

HRID 2097576 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5](Cl)=[N:6][CH:7]=1.[CH:9]([N:22]1[CH2:25][CH:24]([OH:26])[CH2:23]1)([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>>[CH:9]([N:22]1[CH2:25][CH:24]([O:26][C:5]2[CH:4]=[CH:3][C:2]([Br:1])=[CH:7][N:6]=2)[CH2:23]1)([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

Participants

3

Reactant 2

HCID 3304481-(Diphenylmethyl)azetidin-3-olHCID 27344145-Bromo-2-chloropyridine

Product 1

HCID 58073127HCID 58073127, compoundYield 68.5%

Procedure

This compound was prepared by the method outlined for example 5 step 1. Thus 5-bromo-2-chloropyridine (31.31 g, 0.163 mol) and 1-benzhydryl-azetidin-3-ol (38.92 g, 0.163 mol) were reacted to afford title compound (44.14 g, 64%) as light brown solid.

Workup

  1. customThis compound was prepared by the method

Sources & evidence

ORD record
ord-5cfe2d35a2104d8e876130745d61728f
Source dataset
uspto-grants-2013_05
Patent number
US08450346B2

Reaction notes

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