2,6-Lutidine → HCID 58941848, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of methyl 5-(hydroxymethyl)-1,2,3-thiadiazole-4-carboxylate (1.22 g, 0.007 mol) in DCM (20 mL) at 0° C. was added 2,6-lutidine (2.0 mL, 0.018 mol) followed by triisopropylsilyl triflate (2.4 mL, 0.0091 mol). The solution was stirred at 0° C. for 5 minutes. The reaction was then concentrated and purified by flash chromatography to give the desired product (2.0 g, 87%). 1H NMR (400 MHz, CDCl3): δ; MF═C14H26N2O3SSi; LCMS calculated for C14H27N2O3SSi (M+H)+: m/z=331.1.

Provenance & Evidence