1,1'-Carbonyldiimidazole → HCID 58941918, compound

Participants

Reaction Conditions

Reaction Steps

Into a round bottom flask was added N-(3-chloro-4-fluorophenyl)-N′-hydroxy-5-[(triisopropylsilyl)oxy]methyl-1,2,3-thiadiazole-4-carboximidamide (85.0 mg, 0.185 mmol), anhydrous THF (1.1 mL), and N,N-carbonyldiimidazole (55 mg, 0.34 mmol). The reaction was heated to 70° C. for 2.5 h. The reaction was concentrated in vacuo and the crude purified by flash chromatography to give the desired product (89 mg, 99%). MF═C20H26ClFN4O3SSi; LCMS calculated for C20H27ClFN4O3SSi (M+H)+: m/z=485.2.

Provenance & Evidence