Hydrochloric Acid → HCID 58941884, compound

Participants

Reaction Conditions

Reaction Steps

Into a round bottom flask was added 4-(3-chloro-4-fluorophenyl)-3-(5-[(triisopropylsilyl)-oxy]methyl-1,2,3-thiadiazol-4-yl)-1,2,4-oxadiazol-5(4H)-one (89 mg, 0.18 mmol), anhydrous MeOH (1.5 mL), and hydrogen chloride in 1,4-dioxane (1.5 mL, 4.0 M). The reaction was heated to 70° C. for 2.5 h. The reaction was concentrated in vacuo and the crude purified by flash chromatography to give the desired product (52 mg, 86%). MF═C11H6ClFN4O3S; LCMS calculated for C11H7ClFN4O3S (M+H)+: m/z=329.0.

Provenance & Evidence