Methanesulfonyl chloride → HCID 58941889, compound

Participants

Reaction Conditions

Reaction Steps

4-(3-Chloro-4-fluorophenyl)-3-[5-(hydroxymethyl)-1,2,3-thiadiazol-4-yl]-1,2,4-oxadiazol-5(4H)-one was dissolved in anhydrous DCM (2 mL) followed by addition of TEA (26 μL, 0.19 mmol). The reaction was stirred at 0° C. for 15 minutes. Methanesulfonyl chloride (13 μL, 0.17 mmol) was added drop-wise and stirred for 15 minutes at 0° C. The reaction was concentrated in vacuo and the crude purified by flash chromatography to give the desired product (42 mg, 65%). 1H NMR (400 MHz, CDCl3): δ 7.50 (m, 1H), 7.25 (m, 2H), 5.83 (s, 2H), 3.20 (s, 3H). MF═C12H8ClFN4O5S2; LCMS calculated for C12H9ClFN4O5S2 (M+H)+: m/z=406.9.

Provenance & Evidence