Magnesium → HCID 178478019, compound

Participants

Reaction Conditions

Reaction Steps

A solution of (17) (1 equiv) in dry MeOH (0.1 M) was added to magnesium powder (10 equiv) under argon at 0° C. and the resulting suspension was stirred at 0° C. for 1 hour, diluted with DCM (3 volumes) and quenched very slowly with 10% HCl (15 ml). The layers were separated and the organic one was washed with 5% aqueous sodium bicarbonate solution and brine, dried (MgSO4), filtered and concentrated in vacuo. An oil was obtained which was purified by flash chromatography (Hex/AcOEt 5:1 and 1:1) to render 4-(2-chlorophenyl)-1H-1,2,3-triazole (18) as a white crystalline solid (42% yield).

Provenance & Evidence