HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 5-chloro-2-(((5-nitro-1H-pyrazol-3-yl)methyl)thio)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Amino-4-chlorobenzenethiol | HCID 12000 | — |
| Reactant | 3-(chloromethyl)-5-nitro-1H-pyrazole | HCID 136175559 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-chloro-2-(((5-nitro-1H-pyrazol-3-yl)methyl)thio)aniline | HCID 136372389 | 49% |
Reaction Steps
(5-Nitro-1H-pyrazol-3-yl)methanol (524 mg, 3.66 mmol) was first treated with SOCl2 (3 ml) in CH2Cl2 (5 ml) at 35° C. for 2 hrs. The solvent was removed to get a crude 3-(chloromethyl)-5-nitro-1H-pyrazole. Then following General Procedure A, the title compound (515 mg, 49%) was prepared from 2-amino-4-chlorobenzenethiol (161 mg, 1.01 mmol), crude 3-(chloromethyl)-5-nitro-1H-pyrazole, K2CO3 (468 mg, 3.39 mmol) in DMF (3 ml).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08450367B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-ec9285b8240a4a2181bf6b847b897273 |
| Source note | uspto-grants-2013_05 |