HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → (S)-tert-butyl 4-(4-cyanophenyl)-2-methylpiperazine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Fluorobenzonitrile | HCID 14517 | — |
| Reactant | tert-Butyl (2S)-2-methylpiperazine-1-carboxylate | HCID 10081508 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | (S)-tert-butyl 4-(4-cyanophenyl)-2-methylpiperazine-1-carboxylate | HCID 58324511 | 30% |
Reaction Conditions
| Temperature | 110 °C |
|---|
Reaction Steps
(S)-tert-butyl 2-methylpiperazine-1-carboxylate (1 g, 4.99 mmol), 4-fluorobenzonitrile (0.605 g, 4.99 mmol), and K2CO3 (0.897 g, 6.49 mmol) were combined into a vial equipped with a stir bar. The reaction was heated to 110° C. for 48 h. Cooled to RT, diluted with EA and filtered. Concentrated to a clear oil and purified on silica gel (80 g, 10-20% EA in Hex) to give a clear oil (450 mg, 30% yield) which became a crystalline solid upon sitting. [M+H] calc'd for C17H23N3O2, 301; found, 301.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08450323B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-80f10bf7607f4693818de0b91f86f3fc |
| Source note | uspto-grants-2013_05 |