Diisopropylethylamine → (S)-N,3-dimethyl-4-(4-((6-oxo-6,6a,7,8,9,10-hexahydro-5H-dipyrido[1,2-a:3',2'-e]pyrazin-3-yl)methyl)piperazin-1-yl)benzamide

Participants

Reaction Conditions

Reaction Steps

(S)-3-(hydroxymethyl)-7,8,9,10-tetrahydro-5H-dipyrido[1,2-a:3′,2′-e]pyrazin-6(6aH)-one (100 mg, 0.429 mmol), N,3-dimethyl-4-(piperazin-1-yl)benzamide dihydrochloride (131 mg, 0.429 mmol), (cyanomethyl)trimethylphosphonium iodide (167 mg, 0.686 mmol) and N,N-diisopropylethylamine (374 μl, 2.143 mmol) were suspended in propiononitrile (Volume: 1287 μl) and heated in a closed vial at 90° C. for 4 h. The reaction mixture became a dark brown solution. It was cooled to room temperature and purified using HPLC (NH4HCO3 buffered, 20-70% ACN in water). The fractions were concentrated in vacuo and the resulting solid was recrystallized from MeCN (5 mL), filtered off, washed with water (2 mL) and dried in vacuum to afford (S)-N,3-dimethyl-4-(4-((6-oxo-6,6a,7,8,9,10-hexahydro-5H-dipyrido[1,2-a:3′,2′-e]pyrazin-3-yl)methyl)piperazin-1-yl)benzamide (27.4 mg, 0.061 mmol, 14.25% yield) as a light beige solid. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.31-1.57 (m, 3 H) 1.64 (d, J=11.87 Hz, 1 H) 1.85 (d, J=11.37 Hz, 1 H) 2.04 (d, J=11.87 Hz, 1 H) 2.25 (s, 3 H) 2.51-2.70 (m, 5 H) 2.56-2.70 (m, 2 H) 2.74 (d, J=4.29 Hz, 3 H) 2.87 (br. s., 4 H) 3.37-3.45 (m, 2 H) 3.84 (dd, J=11.24, 2.40 Hz, 1 H) 4.50 (d, J=13.14 Hz, 1 H) 6.98 (d, J=1.77 Hz, 1 H) 7.01 (d, J=8.34 Hz, 1 H) 7.61 (dd, J=8.46, 1.64 Hz, 1 H) 7.65 (dd, J=12.25, 1.64 Hz, 2 H) 8.23 (q, J=4.13 Hz, 1 H) 10.48 (s, 1 H); [M+H] calc'd for C25H32N6O2, 449; found, 449.

Provenance & Evidence