4-Methoxyphenylacetic Acid → HCID 46869671, compound

HRID 2097972Notes

Reaction equation

HRID 2097972 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([OH:12])=O)=[CH:5][CH:4]=1.[N:13]1([C:18]2[S:19][CH:20]=[CH:21][C:22]=2[NH2:23])[CH:17]=[N:16][CH:15]=[N:14]1>>[N:13]1([C:18]2[S:19][CH:20]=[CH:21][C:22]=2[NH:23][C:10](=[O:12])[CH2:9][C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=2)[CH:17]=[N:16][CH:15]=[N:14]1

Participants

3

Reactant 2

HCID 76904-Methoxyphenylacetic AcidHCID 68782421HCID 68782421, compound

Product 1

HCID 46869671HCID 46869671, compound

Procedure

The title compound was prepared from 2-(4-methoxyphenyl)acetic acid (233 mg, 1.41 mmol) and 2-(1H-1,2,4-triazol-1-yl)thiophen-3-amine (234 mg, 1.41 mmol) according to protocol B. Retention time (min)=2.847, method [7], MS (ESI) 315.2 (M+H); 1H NMR (300 MHz, CDCl3) δ 9.27 (s, 1H), 8.31 (s, 1H), 7.99 (d, J=5.3 Hz, 1H), 7.83 (s, 1H), 7.22 (d, J=8.1 Hz, 2H), 7.09 (d, J=5.3 Hz, 1H), 6.94 (d, J=8.1 Hz, 2H), 3.87 (s, 3H), 3.72 (s, 2H).

Sources & evidence

ORD record
ord-1060d6f3922c4880ad8401f9df226969
Source dataset
uspto-grants-2013_05
Patent number
US08450363B2

Reaction notes

Loading…