4-Methoxyphenylacetic Acid → 2-(2-(4-Methoxyphenyl)acetamido)-4-methylthiophene-3-carboxamide

HRID 2097973Notes

Reaction equation

HRID 2097973 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([OH:12])=O)=[CH:5][CH:4]=1.[NH2:13][C:14]1[S:15][CH:16]=[C:17]([CH3:22])[C:18]=1[C:19]([NH2:21])=[O:20]>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:9][C:10]([NH:13][C:14]2[S:15][CH:16]=[C:17]([CH3:22])[C:18]=2[C:19]([NH2:21])=[O:20])=[O:12])=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 76904-Methoxyphenylacetic AcidHCID 2938102-Amino-4-methylthiophene-3-carboxamide

Product 1

HCID 687568372-(2-(4-Methoxyphenyl)acetamido)-4-methylthiophene-3-carboxamide

Procedure

The title compound was prepared from 2-(4-methoxyphenyl)acetic acid (1.21 g, 7.22 mmol) and 2-amino-4-methylthiophene-3-carboxamide (1.12 g, 7.22 mmol) according to protocol B. Retention time (min)=1.903, method [1], MS (ESI) 305.0 (M+H).

Sources & evidence

ORD record
ord-b292648d2b1142a58ed9cc7740e14784
Source dataset
uspto-grants-2013_05
Patent number
US08450363B2

Reaction notes

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