4-Methoxyphenylacetic Acid → HCID 46869677, compound

HRID 2097974Notes

Reaction equation

HRID 2097974 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([OH:12])=O)=[CH:5][CH:4]=1.[N:13]1[N:14]([C:18]2[S:19][CH:20]=[CH:21][C:22]=2[NH2:23])[N:15]=[CH:16][CH:17]=1.N1C=CNN1S1C=CC(N)=C1>>[N:15]1[N:14]([C:18]2[S:19][CH:20]=[CH:21][C:22]=2[NH:23][C:10](=[O:12])[CH2:9][C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=2)[N:13]=[CH:17][CH:16]=1

Participants

4

Reactant 3

HCID 76904-Methoxyphenylacetic AcidHCID 68785507HCID 68785507, compoundHCID 178508134HCID 178508134, compound

Product 1

HCID 46869677HCID 46869677, compound

Procedure

The title compound was prepared from (2-(4-methoxyphenyl)acetic acid (1.21 g, 7.22 mmol) and a 1:1 mixture of 2-(2H-1,2,3-triazol-2-yl)thiophen-3-amine and 1-(1H-1,2,3-triazol-2-yl)thiophen-3-amine (431 mg, 2.61 mmol) according to protocol B to give N-(2-(2H-1,2,3-triazol-2-yl)thiophen-3-yl)-2-(4-methoxyphenyl)acetamide. Retention time (min)=5.712, method [7], MS (ESI) 315.0 (M+H); 1H NMR (300 MHz, CDCl3) δ 9.99 (s, 1H), 8.06 (d, J=6.4 Hz, 1H), 7.67 (s, 2H), 7.28-7.31 (m, 2H), 7.02 (d, J=5.7 Hz, 1H), 6.98 (d, J=9.1 Hz, 2H), 3.88 (s, 3H), 3.76 (s, 2H).

Sources & evidence

ORD record
ord-9b51c79d1d2544a1b650f51086707288
Source dataset
uspto-grants-2013_05
Patent number
US08450363B2

Reaction notes

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