2-Amino-4-methylthiophene-3-carboxamide → 4-Methyl-2-(2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamido)thiophene-3-carboxamide

HRID 2097977Notes

Reaction equation

HRID 2097977 reaction equation
[O:1]=[C:2]1[CH2:11][CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]1[CH2:12][C:13]([OH:15])=O.[NH2:16][C:17]1[S:18][CH:19]=[C:20]([CH3:25])[C:21]=1[C:22]([NH2:24])=[O:23]>>[CH3:25][C:20]1[C:21]([C:22]([NH2:24])=[O:23])=[C:17]([NH:16][C:13](=[O:15])[CH2:12][N:3]2[C:4]3[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=3)[CH2:10][CH2:11][C:2]2=[O:1])[S:18][CH:19]=1

Participants

3

Reactant 2

HCID 2938102-Amino-4-methylthiophene-3-carboxamideHCID 167842212-(2-Oxo-1,2,3,4-tetrahydroquinolin-1-yl)acetic acid

Product 1

HCID 687559494-Methyl-2-(2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamido)thiophene-3-carboxamide

Procedure

4-Methyl-2-(2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamido)thiophene-3-carboxamide was prepared from 2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetic acid (0.49 g, 2.38 mmol) and 2-amino-4-methylthiophene-3-carboxamide (0.37 g, 2.38 mmol) according to protocol B Retention time (min)=3.405, method [1], MS (ESI) 344.0 (M+H).

Sources & evidence

ORD record
ord-f120002b52d4420882e5d35af0cc5933
Source dataset
uspto-grants-2013_05
Patent number
US08450363B2

Reaction notes

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