Methyl 2-amino-4-methylthiophene-3-carboxylate → Methyl 4-methyl-2-(2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamido)thiophene-3-carboxylate

HRID 2097978Notes

Reaction equation

HRID 2097978 reaction equation
[O:1]=[C:2]1[CH2:11][CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]1[CH2:12][C:13]([OH:15])=O.[NH2:16][C:17]1[S:18][CH:19]=[C:20]([CH3:26])[C:21]=1[C:22]([O:24][CH3:25])=[O:23]>>[CH3:26][C:20]1[C:21]([C:22]([O:24][CH3:25])=[O:23])=[C:17]([NH:16][C:13](=[O:15])[CH2:12][N:3]2[C:4]3[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=3)[CH2:10][CH2:11][C:2]2=[O:1])[S:18][CH:19]=1

Participants

3

Reactant 2

HCID 2759773Methyl 2-amino-4-methylthiophene-3-carboxylateHCID 167842212-(2-Oxo-1,2,3,4-tetrahydroquinolin-1-yl)acetic acid

Product 1

HCID 53322984Methyl 4-methyl-2-(2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamido)thiophene-3-carboxylate

Procedure

The title compound was prepared from 2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetic acid (0.43 g, 2.09 mmol) and methyl 2-amino-4-methylthiophene-3-carboxylate (0.358 g, 2.09 mmol) according to protocol B. Retention time (min)=6.895, method [7], MS (ESI) 359.1 (M+H).

Sources & evidence

ORD record
ord-f6b666e931d541329b6b51529fee7ab7
Source dataset
uspto-grants-2013_05
Patent number
US08450363B2

Reaction notes

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