Acetamidine monohydrochloride → HCID 178434591, compound

HRID 2097980Notes

Reaction equation

HRID 2097980 reaction equation
Cl.[C:2](=N)([NH2:4])[CH3:3].[NH:6]([C:8]([C:10]1[C:14]([CH3:15])=[CH:13][S:12][C:11]=1[NH:16][C:17](=[O:30])[CH2:18][N:19]1[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH2:22][CH2:21][C:20]1=[O:29])=O)[NH2:7]>>[CH3:15][C:14]1[C:10]([C:8]2[NH:6][N:7]=[C:2]([CH3:3])[N:4]=2)=[C:11]([NH:16][C:17](=[O:30])[CH2:18][N:19]2[C:28]3[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=3)[CH2:22][CH2:21][C:20]2=[O:29])[S:12][CH:13]=1

Participants

3

Reactant 2

HCID 67170Acetamidine monohydrochlorideHCID 68755429N-(3-(hydrazinecarbonyl)-4-methylthiophen-2-yl)-2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamide

Product 1

HCID 178434591HCID 178434591, compound

Procedure

The title compound was prepared from acetimidamide hydrochloride (55 mg, 0.590 mmol) and N-(3-(hydrazinecarbonyl)-4-methylthiophen-2-yl)-2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamide (141 mg, 0.393 mmol) according to the procedure of Example 1.11.2, above. Retention time (min)=4.106, method [7], MS (ESI) 382.1 (M+H); 1H NMR (300 MHz, CDCl3) δ 12.07 (s, 1H), 7.23-7.31 (m, 2H), 7.05-7.23 (m, 2H), 6.57 (s, 1H), 4.86 (s, 2H), 3.02-3.07 (m, 2H), 2.84-2.87 (m, 2H), 2.41 (s, 3H), 2.39 (s, 3H).

Sources & evidence

ORD record
ord-f7c017f46c8f4fec8ec102a1e724ca87
Source dataset
uspto-grants-2013_05
Patent number
US08450363B2

Reaction notes

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