Pyridine-4-amidine hydrochloride → HCID 46869675, compound

HRID 2097981Notes

Reaction equation

HRID 2097981 reaction equation
Cl.[N:2]1[CH:7]=[CH:6][C:5]([C:8](=[NH:10])[NH2:9])=[CH:4][CH:3]=1.[NH:11]([C:13]([C:15]1[S:16][CH:17]=[CH:18][C:19]=1[NH:20][C:21](=[O:31])[CH2:22][C:23]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][CH:24]=1)=O)N>>[CH3:30][O:29][C:26]1[CH:25]=[CH:24][C:23]([CH2:22][C:21]([NH:20][C:19]2[CH:18]=[CH:17][S:16][C:15]=2[C:13]2[NH:11][N:9]=[C:8]([C:5]3[CH:6]=[CH:7][N:2]=[CH:3][CH:4]=3)[N:10]=2)=[O:31])=[CH:28][CH:27]=1

Participants

3

Reactant 2

HCID 2776844Pyridine-4-amidine hydrochlorideHCID 68754038HCID 68754038, compound

Product 1

HCID 46869675HCID 46869675, compound

Procedure

The title compound was prepared from pyridine-4-carboximidamide hydrochloride (157 mg, 1.00 mmol) and N-(2-(hydrazinecarbonyl)thiophen-3-yl)-2-(4-methoxyphenyl)acetamide (Example 1.11.1., 204 mg, 0.668 mmol) according to the procedure described in Example 1.11.2., above. Retention time (min)=2.511, method [7], MS (ESI) 392.1 (M+H); 1H NMR (300 MHz, DMSO-d6) δ 10.52 (s, 1H), 8.87 (d, J=4.5 Hz, 2H), 8.08-8.16 (m, 2H), 7.94 (d, J=5.0 Hz, 1H), 7.67-7.70 (m, 1H), 7.31 (d, J=8.6 Hz, 2H), 7.88 (d, J=8.6 Hz, 2H), 3.88 (s, 2H), 3.67 (s, 3H).

Sources & evidence

ORD record
ord-d3f0876dbd7c4c429e86d5658ce3e027
Source dataset
uspto-grants-2013_05
Patent number
US08450363B2

Reaction notes

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