2-(Quinolin-5-yl)acetic acid → Methyl 4-bromo-2-(2-(quinolin-5-yl)acetamido)thiophene-3-carboxylate

HRID 2097984Notes

Reaction equation

HRID 2097984 reaction equation
[N:1]1[C:10]2[C:5](=[C:6]([CH2:11][C:12]([OH:14])=O)[CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[NH2:15][C:16]1[S:17][CH:18]=[C:19]([Br:25])[C:20]=1[C:21]([O:23][CH3:24])=[O:22]>>[Br:25][C:19]1[C:20]([C:21]([O:23][CH3:24])=[O:22])=[C:16]([NH:15][C:12](=[O:14])[CH2:11][C:6]2[CH:7]=[CH:8][CH:9]=[C:10]3[C:5]=2[CH:4]=[CH:3][CH:2]=[N:1]3)[S:17][CH:18]=1

Participants

3

Reactant 2

HCID 205339092-(Quinolin-5-yl)acetic acidHCID 68754257Methyl 2-amino-4-bromothiophene-3-carboxylate

Product 1

HCID 68754644Methyl 4-bromo-2-(2-(quinolin-5-yl)acetamido)thiophene-3-carboxylate

Procedure

Methyl 4-bromo-2-(2-(quinolin-5-yl)acetamido)thiophene-3-carboxylate was prepared from 2-(quinolin-5-yl)acetic acid (427 mg, 2.18 mmol) and methyl 2-amino-4-bromothiophene-3-carboxylate (514 mg, 2.18 mmol) according to protocol A. Retention time (min)=1.660, method [1], MS (ESI) 405.0 (M+H).

Sources & evidence

ORD record
ord-a28df8385b564f58a4e2bdc409d29faf
Source dataset
uspto-grants-2013_05
Patent number
US08450363B2

Reaction notes

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