HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2097989Generated: October 27, 2026
Hydrochloric Acid → 2-(4-(3-(Piperidin-1-yl)propoxy)phenyl)acetic acid
https://huagongshe.com/reaction/2097989
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methyl 2-(4-(3-(piperidin-1-yl)propoxy)phenyl)acetate | HCID 68756457 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 2-(4-(3-(Piperidin-1-yl)propoxy)phenyl)acetic acid | HCID 44769635 | — |
Reaction Steps
To a stirring mixture of methyl 2-(4-(3-(piperidin-1-yl)propoxy)phenyl)acetate (570 mg) in HOAc (5 mL) was added 6N HCl (10 mL). The reaction mixture was warmed to 80° C. for 2 h. The crude product mixture was concentrated under reduced pressure and directly taken to the next reaction without further purification. Method[1], MS (ESI) 278.1 [M+H], Retention time=0.666 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08450363B2 |
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| Source dataset | uspto-grants-2013_05 |
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| ORD ID | ord-c2baa82d69084ca194b3078dc97b1003 |
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| Source note | uspto-grants-2013_05 |
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