2-(Isoquinolin-5-YL)acetic acid → Methyl 4-bromo-2-(2-(isoquinolin-5-yl)acetamido)thiophene-3-carboxylate

HRID 2097994Notes

Reaction equation

HRID 2097994 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([Br:11])[C:6]=1[C:7]([O:9][CH3:10])=[O:8].[CH:12]1[C:21]2[C:16](=[C:17]([CH2:22][C:23](O)=[O:24])[CH:18]=[CH:19][CH:20]=2)[CH:15]=[CH:14][N:13]=1>>[Br:11][C:5]1[C:6]([C:7]([O:9][CH3:10])=[O:8])=[C:2]([NH:1][C:23](=[O:24])[CH2:22][C:17]2[CH:18]=[CH:19][CH:20]=[C:21]3[C:16]=2[CH:15]=[CH:14][N:13]=[CH:12]3)[S:3][CH:4]=1

Participants

3

Reactant 2

HCID 120187082-(Isoquinolin-5-YL)acetic acidHCID 68754257Methyl 2-amino-4-bromothiophene-3-carboxylate

Product 1

HCID 59636688Methyl 4-bromo-2-(2-(isoquinolin-5-yl)acetamido)thiophene-3-carboxylate

Procedure

This compound was prepared from methyl 2-amino-4-bromothiophene-3-carboxylate and 2-(isoquinolin-5-yl)acetic acid using protocol A. Method[1], MS (ESI) 404.9 [M+H], Retention time=1.678 min.

Sources & evidence

ORD record
ord-9c4730fb3f75436ba775726930df8219
Source dataset
uspto-grants-2013_05
Patent number
US08450363B2

Reaction notes

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