4-bromo-3-(4H-1,2,4-triazol-3-yl)thiophen-2-amine → HCID 56658304, compound

HRID 2098022Notes

Reaction equation

HRID 2098022 reaction equation
[O:1]=[C:2]1[CH:7]=[CH:6][N:5]2[N:8]=[CH:9][CH:10]=[C:4]2[N:3]1[CH2:11][C:12]([OH:14])=O.[Br:15][C:16]1[C:17]([C:22]2[NH:26][N:25]=[CH:24][N:23]=2)=[C:18]([NH2:21])[S:19][CH:20]=1>>[Br:15][C:16]1[C:17]([C:22]2[NH:26][N:25]=[CH:24][N:23]=2)=[C:18]([NH:21][C:12](=[O:14])[CH2:11][N:3]2[C:2](=[O:1])[CH:7]=[CH:6][N:5]3[N:8]=[CH:9][CH:10]=[C:4]23)[S:19][CH:20]=1

Participants

3

Reactant 2

HCID 596366864-bromo-3-(4H-1,2,4-triazol-3-yl)thiophen-2-amineHCID 68786002HCID 68786002, compound

Product 1

HCID 56658304HCID 56658304, compound

Procedure

The title compound was prepared from 2-(5-oxopyrazolo[1,5-a]pyrimidin-4(5H)-yl)acetic acid (39 mg, 0.203 mmol) and 4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-amine (25 mg, 0.102 mmol) according to protocol A. Retention time (min)=2.451, method [7], MS (ESI) 420.0 (M+H); 1H NMR (300 MHz, CDCl3) δ 8.28 (d, J=8.5 Hz, 1H), 7.83 (s, 1H), 7.77 (d, J=2.6 Hz, 1H), 6.97 (s, 1H), 6.25 (d, J=7.9 Hz, 1H), 5.94 (d, J=2.6 Hz, 1H), 4.98 (s, 2H).

Sources & evidence

ORD record
ord-e61a361dce044dda8a476dcbd3567e93
Source dataset
uspto-grants-2013_05
Patent number
US08450363B2

Reaction notes

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