4-bromo-3-(4H-1,2,4-triazol-3-yl)thiophen-2-amine → CID 46869493

HRID 2098025Notes

Reaction equation

HRID 2098025 reaction equation
[O:1]=[C:2]1[CH:7]=[CH:6][N:5]2[N:8]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:10]=[C:4]2[N:3]1[CH2:15][C:16]([OH:18])=O.[Br:19][C:20]1[C:21]([C:26]2[NH:30][N:29]=[CH:28][N:27]=2)=[C:22]([NH2:25])[S:23][CH:24]=1>>[Br:19][C:20]1[C:21]([C:26]2[NH:30][N:29]=[CH:28][N:27]=2)=[C:22]([NH:25][C:16](=[O:18])[CH2:15][N:3]2[C:2](=[O:1])[CH:7]=[CH:6][N:5]3[N:8]=[C:9]([C:11]([F:12])([F:13])[F:14])[CH:10]=[C:4]23)[S:23][CH:24]=1

Participants

3

Reactant 2

HCID 596366864-bromo-3-(4H-1,2,4-triazol-3-yl)thiophen-2-amineHCID 687844542-(5-oxo-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-4(5H)-yl)acetic acid

Product 1

HCID 46869493CID 46869493

Procedure

The title compound was prepared from 2-(5-oxo-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-4(5H)-yl)acetic acid (63 mg, 0.244 mmol) and 4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-amine (30 mg, 0.122 mmol) according to protocol A. Retention time (min)=4.975, method [7], MS (ESI) 488.0 (M+H); 1H NMR (300 MHz, DMSO-d6) δ 8.79 (d, J=7.4 Hz, 1H), 8.61 (bs, 1H), 7.32 (s, 1H), 6.96 (s, 1H), 6.45 (d, J=7.4 Hz, 1H), 5.01 (s, 2H).

Sources & evidence

ORD record
ord-f03db5bf0e5b4afc936ce1686ab504b4
Source dataset
uspto-grants-2013_05
Patent number
US08450363B2

Reaction notes

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