HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 2-(3-Fluoroquinolin-8-yl)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 8-Bromo-3-fluoroquinoline | HCID 12189469 | — |
| Reactant | HCID 178451183 | HCID 178451183 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-(3-Fluoroquinolin-8-yl)acetic acid | HCID 68755991 | — |
Reaction Steps
The title compound was prepared from 8-bromo-3-fluoroquinoline (568 mg, 2.51 mmol) and 0.5 M (2-Tert-butoxy-2-oxoethyl)zinc(II) chloride according to Protocol P, accept that the ester was converted to the acid using NaOH and MeOH in dioxane. Method [7] retention time 2.39 min by HPLC (M+=206).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08450363B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-e332cca8319043eea1a8cb745b931289 |
| Source note | uspto-grants-2013_05 |